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A minireview. Front Biosci. Jeon, S. Denko, N. Hypoxia, HIF1 and glucose metabolism in the solid tumour. Cancer 8 , — Liu, W.

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Targeted genes and interacting proteins of hypoxia inducible factor Bioche Mol. Benita, Y. An integrative genomics approach identifies Hypoxia Inducible Factor-1 HIF-1 -target genes that form the core response to hypoxia. Nucleic Acids Res. Kelly, D. Transcriptional regulatory circuits controlling mitochondrial biogenesis and function. Genes Dev.

Bioenergetic And Growth

Bruni, F. Nuclear respiratory factor 2 induces the expression of many but not all human proteins acting in mitochondrial DNA transcription and replication. Larsson, N. Mitochondrial transcription factor A is necessary for mtDNA maintenance and embryogenesis in mice.

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Levesque, M. Single-chromosome transcriptional profiling reveals chromosomal gene expression regulation. Methods 10 , — Selak, M. Cancer Cell 1 , 77—85 Kaelin, W. The Von Hippel-Lindau tumor suppressor protein: O 2 sensing and cancer. Seidel, S. A hypoxic niche regulates glioblastoma stem cells through hypoxia inducible factor 2 alpha. Brain , — Dickinson, A. The regulation of mitochondrial copy number in glioblastoma cells.

Cell Death Diff. Sakamoto, K. EMBO J. Thomson, D. Skeletal muscle and heart LKB1 deficiency causes decreased voluntary running and reduced muscle mitochondrial marker enzyme expression in mice. McGee, S. AMPK-mediated regulation of transcription in skeletal muscle. Li, Y. Mayr, B. Transcriptional regulation by the phosphorylation-dependent factor CREB. Jang, T. Cancer , — Ferreira, D.

Lopez-Camarillo, C. Lipoprotein internalisation induced by oncogenic AMPK activation is essential to maintain glioblastoma cell growth. Cancer 50 , — Saito, Y. AMPK protects leukemia-initiating cells in myeloid leukemias from metabolic stress in the bone marrow.

Cell Stem Cell 17 , — Mo, J. Papandreu, I. HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption. AMP-activated protein kinase phosphorylates retinoblastoma protein to control mammalian brain development. Cell 16 , — Pooya, S.

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The tumour suppressor LKB1 regulates myelination through mitochondrial metabolism. Komurov, K. NetWalker: a contextual network analysis tool for functional genomics. BMC Genom. Ernst, J.